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By pumping the accumulated, unbound cytosolic catecholamines backward across the plasma membrane and safely into the extracellular synaptic space, the neuron is able to maintain its free cytoplasmic neurotransmitter levels below toxic thresholds , directly protecting itself from oxidative cell death and preserving neuronal viability (Underhill et al., 2021)

J Autism Dev Disord 2009;39:5446

Thus, vitamin A could reduce dopaminergic cell loss and reduce the underlying neuroinflammation and synuclein aggregation (Ono and Yamada 2007

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10.1073/pnas.2332354100 Proc